Introduction. The static pool rates are dropping steadily
now, indicating the end of the first, hopefully only, wave of the coronavirus. The
rates are now 12% for the U.S. and 8% globally. This week adds two topical sections: a deeper dive into the recent spikes in the South and Southwest as
well as a preview the race against the clock for a coronavirus vaccine.
This article in the Wall
Street Journal, free of charge, outlines what we know about the coronavirus
and how it infects people and what to look out for; Johns
Hopkins Medicine has issued this handy reference. The
New York Times has also made a user-friendly tool available for non-subscribers.
As usual, this analysis relies also upon data collected by Johns Hopkins Coronavirus Resource
Centre and aggregated by Worldometre.
Past week global and U.S. review. The United States has re-accelerated
her growth rate in confirmed cases to 13.0%, due in large part (at least for
now) to the ramping up of testing. American infection rates have edged by the global
growth rate of 12.7%. The hot-spots to focus on remain emerging nations in Africa,
Eurasia, and Latin America. The places leading the rise in infections
include Brazil, the Indian sub-continent, México, and South Africa.
Many of the poorer countries of these regions have suspect data
integrity in their reporting. The global mortality run rate is now
higher than that of the United States – at 4.8% to 4.6% -- due to increased
testing in the U.S. as well as the American roll-out of mitigating medications,
principally remdesevir and dexamethasone.
The spread
into the rural areas of the United States continues; these areas host fewer
doctors with fewer resources.
The second wave now
emerging across the world works more like a second wave among industrialised
countries but a deferred first wave for developping nations plus the Southern
and Southwestern U.S. states. In reviewing the eight family clusters tracked
each week, the following three reasons explain the mortality run rates so far
above the national average (i.e.,7.8% versus 4.6%).
- Unless there is some Asiatic
genome that confers a robust defence against this virus upon inhabitants of the
Asian Pacific Rim, the coronavirus appears to have mutated while it migrated
west through Europe into the Eastern Americas. The Western U.S. states have
managed their epidemics better, perhaps with a less malignant virus. Remember the State of Washington three months
ago (before the Northeast took off)? As it turns out, as rough a start as
Washington faced, Governor Inslee has managed, heroically, to keep the rates to moderate
intensity (as shown below).
- There was a steep
learning curve to overcome with this uniquely new coronavirus. What previous experience had taught us as prudent in March (sending elderly patients to nursing homes) proved
counter-productive.
- Most of these clusters lie
in urban areas with substantial Black and Brown populations that have
suffered disproportionately due to higher levels of "co-morbidities" (i.e.,
kidney failure, blood pressure, diabetes, and obesity). Additionally, a higher
percentage of Hispanics and Blacks have had to report to work as ‘essential’
employees (e.g., bus-drivers, garbage collectors, etc.). This racially
skewed hazard reflects in part the systemic racism argued by Black Lives
Matter and likely explains
part of the Black-led rebellion currently taking place.
- More densely populated
areas tend to transmit the virus more quickly.
Pittsburgh
has endured a 30% growth rate in the past week, with infections largely afflicting people
under forty. This demographic likely reflects increased testing. Hospitalisation rates are
also increasing slowly in Steelers country. Fortunately, Pittsburgh has superb
teaching and general service hospitals that should be able to absorb any new
patient-load. Elsewhere, in the other seven family clusters, growth rates hover
around 1-2% with a mortality up-tick in New York metro.
The tri-state triumvirs of Governors Cuomo (D-NY), Lamont (D-CT), and Murphy
(D-NJ) have been quick to preserve their heard-earned momentum gained
from the ordeal of the past four months. Among possible restrictions, these
states are imposing
quarantine requirements on people entering from states with spikes in
infections including California, the Carolinas, and Idaho (sic). A special
section to follow will analyse these 'spike' states.
Grading the Trump response. The Administration has had to
overcome the consequences of budget-cutting into the bone; an early mis-step by
trying to go it alone (i.e., turning down test kits from the W.H.O.); a
two-to-three week delay imposed by the politics of a partisan impeachment; as
well as, poor public relations management by the President himself (e.g., resorting
to the blame-game and making ill-advised statements). Most Americans view the Trump Administration’s management of
the flu as illustrated below.
Despite the loss of credibility and many self-imposed
hurdles, President Trump gets a “B-“ for the following reasons.
- The U.S. has caught up to its peer group in testing.
- The United States Government (U.S.G.) is finally firing on all cylinders
for mitigating medicines and developing a vaccine.
- The Public-Private Partnership initiated in March is bringing
to bear the industrial capacity still in the U.S. on the bulk production of
protective and life-saving equipment.
- The painful lock-down has flattened the curve, though
a rash of new cases spreads throughout the South and Southwest.
- Deaths per million for the U.S., 399, are well below
those of many of the Western European nations, ranging from 536-843 (i.e.,
Belgium, France, Great Britain, Italy, Spain, and Sweden).
The Spikes: ¿new wave, used wave, loosed wave? The first wave has ended in the
areas hit hardest by the onset of the coronavirus contagion. While many
Southern and Southwestern states are reporting substantial spikes in confirmed
cases, as addressed in last week’s letter, mortality rates apparently remain
low.
- Arizona confirmed cases up 32% (to some 87,500 cases) with a
mortality run rate of 2.2%;
- California confirmed cases up 20% (to some 250,000 cases) with
a mortality run rate of 2.5%, but the state is taking action this July 4th week-end;
- Florida confirmed cases up 38% (to some 170,000 cases) with
a mortality run rate of 2.1%;
- Georgia confirmed cases up 21% (to some 85,000 cases) with a
mortality run rate of 3.3%;
- Oklahoma confirmed cases up 18% (to some 15,000 cases) with
a mortality run rate of 2.7%; as well as,
- Texas confirmed cases up 29% (to some 185,000 cases) with a
mortality run rate of 1.4%.
These data look like good and bad news: bad news of rapidly increasing case-loads
(i.e., up 26% for these six states) but apparently good news of declining mortality run rates. This
conclusion is not really warranted. In actuality, what one reads here is bad news in the number
of cases and ‘not-as-bad’ news of mortality as deaths rising 7.2% to 17,435 victims inside these six states.
Additionally, there is the effect of lag-times of infection to interment. The initial
inference drawn here is that these states are betting they can distribute a vaccine
before a spike of critical care cases forces as death wave across the country. The
20-25day progression from initial infection to critical care will kick in later
for some states than others.
As cases eventually taper off in these and all other states,
deaths will continue to rise for some period of time. The ability of the more rural
states to manage increased hospitalisations and for patients to access care
will be a decisive factor, good or bad. Per the
article composed three months ago, the base case remains high at 335,000 while
the revised best case of 175,000 hopefully will better reflect the unfolding
reality. The following factors will determine the number of eventual
deaths in the busted hustings:
- level of transmission (i.e., ¿how many millions infected,
mostly asymptomatic?);
- proximity to a hospital or well-equipped clinic;
- number of qualified doctors nearby and available; and
- level of Medicaid expansion under Obamacare.
Analysing the rural reach. To test the urgency of the rural
states and those with spikes presently in force, I have taken the number of
deaths in each state and applied the percentage of those deaths to the
host-state’s population. Then I apply that percentage to the U.S. population to
enable comparability of data among states with populations ranging in size from under one to almost forty million.
These examples of computation suffice for Colorado and Maryland.

The states featured below include those hosting whole or
partial clusters studied each week; states where only one or two of my extended
family live (i.e., below the line in the upper-most section); states analysed last week; other states quarantined by Connecticut,
New Jersey, and New York; as well as, additional states of interest. In evaluating the
urgency of the current local coronavirus contagion, I establish the following
benchmarks based upon the rate of confirmed relative to populations of the
United States, New York metro, and, the whole wide fuckin’ world.
- VERY HIGH = at or above 250,000
- HIGH = at or above 130,000
- MODERATE = at or above 50,000
- LOW = at or above 30,000
- VERY LOW = at or below 29,999
The current death toll in the United States approaches 130,000. Without New York metro that mortality level approximates 92,500. If the American people were to suffer the same percentage of deaths as the rest of the world, that toll would 20-25,000.
The currently popular notion that upwards of 90% of
the infections are undiagnosed strikes me as wishful thinking. In any case,
if that assertion be true, the mortality run rate will still be 5x that of the
flu in 2019; this coronavirus contagion is not simply the flu by another name. The
magnitude of impact imposed by this virus, if we are lucky, may be like that of the first wave of the
1918 Flu before it mutated murderously ending with 2.3% mortality run rate.
The race of the century already, or the vaccine rush. Aside
from the second wave, the question of the development of a safe, effective, and
timely vaccine remains paramount. The opening remarks
by Senator Blunt (R-MO) in a hearing this week to assess the progress
toward a vaccine provides a concise overview of the state of development. Three looming challenges confront the companies racing
to develop the vaccine for distribution in early 2021.
- Most important is the ‘rush to failure’, or relaxing testing
strictures to expedite development and distribution of the vaccine. A failed
vaccine might not only prove ineffective, but it could exert negative unintended consequences like side effects.
- Next is the scientific question of the mutation of the virus
so that the vaccine becomes quickly dated. Testimony by leading U.S.G. experts
reflects a collective view, if not complete consensus, that this novel coronavirus
is not apt to change its RNA composition significantly enough to undermine the
effectiveness of the vaccine.
- Last is the concern over distribution and availability.
Those candidates being funded in part by the U.S. share a
common ability to multiply production quickly to make millions or a billion doses
available quickly. The question of availability translates also into pricing.
The Bayh-Dole Law
of 1980 provides for the commercialisation of U.S.G. funded research.
While instrumental in launching an innovation wave during the
past forty years, Bayh-Dole has created two basic political problems in the
case of a vaccine rushed to market. One is the pricing of the developped pharmaceutical
products. The argument here is why American consumers should pay monopolistic
prices for products their tax dollars helped develop.
Representative
Alexandria Ocasio-Cortez argues this point with the C.E.O. of a company
that has benefitted enormously from these legislated subsidies. The issue that critics raise
argues that the development and marketing risk of the product has been transferred
largely to universities and the U.S.G. and, therefore, companies should not
gain the out-sized rewards of monopolitic pricing for risks unassumed.
The other political question remains one of licensing. If a
drug is developped and the U.S.G. seeks to contain the price to increase its
availability to COVID-19 sufferers as well as to recover the subsidies of the
tax-payers, companies may simply refuse to produce and prevent others from levering their intellectual property. In theory such intellectual property -- the formula of the vaccine in this case -- is protected by a patent to permit exclusive used by its owner for twenty years.
To work around this scenario, many countries have compulsory
licensing provisions that allow the government to intervene and oversee manufacture through the "licensing", or renting, the intellectual property out to a third party. This "licensee" (i.e., the government hired company) then prices the product at a level affordable to consumers yet sufficient for a ‘fair’ return to the third party producer. Of course, that 'fair' return is not etched in stone and varies
among contentious stake-holders.
It may be, for example, set at 15%, or the typical
yearly return-on-investment (R.o.I.) for U.S. equity markets. In cases where the development risk is not transferred to tax-payers through Bayh-Dole (i.e., assumed by the companies themselves), such a 'normal' return does
not create the profit necessary for pharmaceutical companies to absorb costly losses endured on most new
drugs that fail in testing or in the market.
Senator Chris Murphy (D-CT) implies that the language of the Bayh-Dole statute
itself – that products be taken to the market “at reasonable terms” – allows for
the practice of compulsory licensing. Two big issues with compulsory licensing
need to be addressed.
- Most overseas laws for compulsory licensing allow
for several years of non-production by the drug company before the government
can intervene, an unworkable provision in the face of this COVID-19 pandemic.
- The real-life practice of compulsory licensing
is not working too well thus far, at least in India. Competing interests and
corporate cronyism appear to subvert the implementation. More likely, governments
in emerging markets (e.g., India) use this ‘last-resort’ as a lever in
negotiating price limits.
Beating the odds and data update. As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). .
- World: 10,997,799 cases (up 12.7%); 524,157 deaths (up 6.4%); 4.8% mortality rate; one case for every 698 people and one death for every 14,660 people
- United States: 2,816,131 cases (up 13.0%); 125,980 deaths (up 3.6%); 4.6% mortality rate; one case for every 118 people and one death for every 2,540 Americans
==========
- Baltimore-Annapolis: 23,790 confirmed cases; 4.7% mortality rate; one death for every 2,502 people
- Boston and the Cape: 63,451 confirmed cases; 7.3% mortality; one death for 1,002 people
- Chicago proper: 91,381 confirmed cases; 5.0%; one death per 858 people
- Colorado statewide: 33,352 cases; 5.1%; one death per 3,394
- Detroit metro: 44,298; 10.9%; 1 death per 886
- New York metro: 455,813; 8.5%; 1 per 584
- New York CITY: 216,362; 10.7%; 1 per 362
- Manhattan Island 26,866; 9.1%; 1 per 664
- Philadelphia metro: 55,498; 7.5%; 1 per 1,462
- Pittsburgh metro: 5,060 cases*; 6.3%; 1 per 7,382
==========
Second Wave Anticipation. While a second wave remains likely, the question remains its magnitude. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place? Answer: approaching adequacy with granular data but people slow to adopt tracing apps.
- Will the states, as a group, have re-opened too soon or too laxly? Answer: spikes in confirmed cases in the South and Southwest shrouding growth in the number of deaths.
- How much will the current protests of George Floyd's murder re-accelerate penetration?Answer: of the states catalysing the Black-led rebellion, only California has seen a significant increase in confirmed cases; state taking action during July 4th week-end.
- Will the virus have mutated and, if so, for the worse or better? Answer: has and continues to mutate, though not enough to undermine proposed vaccines.
- How long will people prove to be immune who have survived the illness already? Answer: only time will tell; some evidence of either re-infection or protracted infection.
- How quickly can a safe and effective vaccine be developped and tested? Answer: progress on mitigating drugs and steroids; vaccine targeted for late 2020 or early 2021
- How efficiently can, and comprehensively will, the vaccine be distributed? Answer: distribution may begin by January 2021; pricing concerns.
- How deep will the penetration of COVID-19 be in the rural areas? Answer: slow progression continues and now accelerating; mortality rates remain low.
* confirmed cases up 30% for PGH metro
BACK-STORY
Johns Hopkins University and
Worldometer provide competing digital data of the coronavirus contagion. These data are close to real-time. These sources underlay my prediction of a 3.6% mortality run-rate in the first year (i.e., the optimistic release time of a vaccine) and my mistrust of the statistics coming out of China, for example as at 22apr20:
- 81% of the cases and 97% of the deaths supposedly confined to Hubei Province with 4% of China's population;
- Shanghai with 27 million people, 639 cases, and seven deaths (¿REALLY?); as well as,
- Peking with a population of 20 million,593 cases, and eight deaths (¿Too good to be true?).
- My family on both sides tend to cluster in Pittsburgh, New York, Detroit, Boston, Colorado, Chicago, Maryland, and Philadelphia.
Every Friday, I use the sources of the linked above to calculate out mortality rates and cases to see how the pandemic is progressing in my personal red-zones.
NOTES on MORTALITY RATES
The static pool looks at the death rate relative to the total number of 'resolved' cases. The unresolved cases are those people in the states of initial infection (i.e., identified at first); convalescence (i.e., on the mend); and, critical care (i.e., on ventillators and other extraordinary measures . . . in the R.C. sense). The run-rate is simply a percentage of currently identified cases resulting in death.
Depending upon one's interpretation of the arrayed data, the difference between the two rates may indicate that likelihood of increase or decrease of future case-based (i.e., run-rate) mortality rates; the length of time and percentage of mortality of critical care cases; the length of time for convalescence; and, larger recognition, response, and resolution lags vis à the unseen and unsightly monster.
Since I am not an epidemiologist and have forgotten most of my baby statistics from school,
it is S.W.A.G.-time (i.e., scientifically wild-assed guess) on any conclusions I draw. You may well have your own. One thing I do know: when this virus has worked its way all they way through this year or, more likely, this year and next, the static pool and run rates will converge.
The question probably keeping epidemiologists and medical first responders up late at night is how far the static pool rates will come down and how far with run will go up (and flatten out) before that convergence occurs. In my S.W.A.G. linked above of 3.6%, I view the death rates and levels of patients in critical care to provide an instrumental if inscrutable hint.
Friday numbers as at 26jun20
Static pool analysis.The static pool mortality rates declined again, with the United States accelerating toward the end of the week, to the 12.8% level; global static pool rates ended the week at 8.8%. The current wave of the pandemic is ending in Europe but lingers in the U.S. Cases grew by 14% globally, 11% in America and 5% in Europe. The Americas as well as sub-Saharan Africa and the Indian sub-continent lead the current global quickening. CRITICAL NOTE: findings by the Centre for Disease Control indicate that 'co-morbidities' (i.e., diabetes, obesity, hyper-tension as well as pulmonary and kidney problems) erase the advantage of youth. That is to say, by way of example: a twenty year old diabetic is as vulnerable to dying from COVID-19 as an eighty year old without diabetes.
Review of U.S. and international trends. The challenge for the United States remains one of speed of deceleration of infection rates. Specifically, the U.S. infection and death rates are not dropping as quickly as other nations stricken hard by COVID-19, with the exceptions of Brazil, India and Sweden. The source of the slower deceleration for the U.S. remains uncertain, though the increased testing has inflated the number of cases as today's presentation by the Coronavirus task force indicates. Apparently, younger people represent most of the new infections and are largely asymptomatic.
Interestingly, Dr Birx later emphasised the importance of her working with community leaders as the tracking data are almost granular enough to infer the course of the contagion. The big story this week was the continued proliferation of confirmed cases throughout the South and Southwest. Consequently, I decided to take a look at the states most mentioned -- Arizona, California, Florida, Texas -- as well as Oklahoma back to May 23rd.
(Unfortunately, I got the two May dates off by a day, but the information is still usable.) The start-date came before Decoration Day as well the murder of George Floyd and the ensuing protests. Arguably, these two events will prove, in hind-sight, to be inflection points. The onset of the Summer travel season and the street demonstrations broke down the discipline of social distancing. In many venues, people did not wear masks. Though a smaller state, Oklahoma hosted a rally by President Trump; I included her to look for any immediate consequence. Below are the data on new cases and deaths in the six states.

As one can see, while the infection rates have increased materially, the mortality has declined and now represents a significant improvement over both the 5.1% global and national run-rates. The U.S. mortality rate has much improved over the last six weeks. These six states compare even more favourably with the composite data for the eight clusters under review, which showed only a 1.7% growth in confirmed cases this week but a 7.8% mortality rate (versus 7.6% the previous week due to an apparent spike in Northern Jersey).
Implications of new spikes. Despite the evident brain-power of the U.S. doctors, epidemiologists, and scientists finally being brought to bear on the U.S. epidemic, the results still lag much of the rest of the world. From what I can tell, there is a twenty to twenty five day interval between infection's first contact and the progression ultimately into critical care for full-blown COVID cases. So increasing mortality rates, if they are to manifest, should make themselves felt about now, or imminently at the latest. The concern remains that of a second wave, now expected to coincide with the Autumn flu season, which could prove a deadly combination.
Europe is set to limit entry by Americans, Russians, and Brasilians due to the spikes in cases across the country. Notwithstanding, the good news this week of the efficacy of certain steroids in mitigating the full blown COVID illness, the fate of Americans may well lie in a race against the clock to test out a vaccine and have it widely distributed by March 2021. This timeliness becomes important in face of some twenty million Americans apparently infected and some 85% not reporting for various reasons.
NOTE on Idaho. Please note there was a mention in Dr Birx's remarks of an inflection taking place in Idaho. After an initial spike in April, Idaho calmed down until the end of May. Of her 5,149 cases, 45-50% have been confirmed in the last month. Idahoans appear to be a hearty crew with a mortality run rate of only 1.7%. Only one of every 347 have contracted the virus and only one of 19,637 actually succumb to it; these are the best odds of any of the McDonnell clusters.
Beating the odds and data update. As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). .
- World: 9,752,937 cases (up 14%); 492,695 deaths (up 8%); 5.1% mortality rate; one case for every 787 people and one death for every 15,596 people
- United States: 2,491,672 cases (up 11%); 125,980 deaths (up 5%); 5.1% mortality rate; one case for every 133 people and one death for every 2,640 Americans
==========
- Baltimore-Annapolis: 22,542 confirmed cases; 4.8% mortality rate; one death for every 2,599 people
- Boston and the Cape: 62,696 confirmed cases; 7.2% mortality; one death for 1,020 people
- Chicago proper: 88,650 confirmed cases; 5.1%; one death per 878 people
- Colorado statewide: 31,796 cases; 5.3%; one death per 3,451
- Detroit metro: 43,143; 11.1%; 1 death per 896
- New York metro*: 451,703; 8.4%; 1 per 597
- New York CITY: 214,070; 10.5%; 1 per 374
- Manhattan Island 26,533; 9.1%; 1 per 674
- Philadelphia metro: 54,032; 7.5%; 1 per 1,497
- Pittsburgh metro: 3,891 cases; 8.1%; 1 per 7,571
==========
Second Wave Anticipation. While a second wave remains likely, the question remains its magnitude. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place? Answer: approaching adequacy with granular data on community spread; tracing still to follow.
- Will the states, as a group, have re-opened too soon or too laxly? Answer: thus far okay with high growth rates of infection with mortality rates 40-60% of national average.
- How much will the current protests of George Floyd's murder re-accelerate penetration?Answer: concerns raised since fourteen members of Trump advance team infected.
- Will the virus have a seasonal effect (e.g., not prolific in hot weather)? Answer: NO.
- Will the virus have mutated and, if so, for the worse or better? Answer: has and continues to mutate, though recently not for the worse.
- How long will people prove to be immune who have survived the illness already? Answer: only time will tell; some evidence of either re-infection or protracted infection.
- How quickly can a safe and effective vaccine be developped and tested? Answer: progress on mitigating drugs and steroids; vaccine targeted for late 2020 or early 2021
- How efficiently can, and comprehensively will, the vaccine be distributed? Answer: Dr Fauci says widespread distribution may be possible by March 2021; pricing concerns.
- How deep will the penetration of COVID-19 be in the rural areas? Answer: slow progression continues and now not accelerating; mortality rates remain low.
Friday numbers as at 19jun20
Static pool analysis.The static pool mortality rates continued to decline, especially during mid-week for the United States, from 15% to 14% domestically and by half a percentage point (to 9.5%) globally as the coronavirus contagion matures on the back-end of what will likely be a first wave. Cases are increasing more rapidly in certain parts of the world, largely in the Middle East, Pakistan, and India. One must keep in mind two points:
- sharp increases off of a small number of cases (e.g., China’s low denominator [sic]); and,
- varying levels of reporting transparency.
Review of emerging U.S. and international trends. The challenge for the United States remains one of speed of the deceleration. Specifically, the U.S. infection and death rates are not dropping as quickly as other nations stricken hard by COVID-19, with the exceptions of Brazil and Russia. Unfortunately, I can not say whether the U.S.’s slower deceleration reflects the onset of a second wave as the first wave tapers off or whether the country’s testing tends to inflate the numbers (since 90%+ of the cases are mild worldwide) to create that appearance.
Florida’s rates apparently defy the argument of more testing unearthing more asymptomatic cases. The politics of COVID-19 becomes more difficult to separate out of the epidemiological challenges of a possibly pending second wave. Vice President Pence argues that the elevation of the number of confirmed cases reflects the increasing thoroughness of testing throughout the United States.
Many officials and public commentators contest these claims, often accusing the Vice President of lying. Keeping in mind my limitations in assessing the trends of disease-related data and the meaning of those data themselves as well as looking at the numbers in the Johns Hopkins site, Worldometer, the New York Times, the BBC, and NPR, I believe that it is too soon to tell.
While the spread of the virus slows in much of the country, one must note some disturbing facts amid the improving news for the states that have been more disciplined in mitigating the coronavirus contagion.
¿What's up with the McDonnells and the Trump Administration?On the plus side, the areas under review witnessed slow growth rates in confirmed cases and deaths at 2% each, one-fifth and one-half the national rates, led by significantly decelerating increases of 1-2% in New York, Detroit, and Boston. Kudos to Governors Cuomo (D-NY), Whitmer (D-MI), and Baker (R-MA). The presence of inner city teaching hospitals is beginning to show as mortality run rates in Boston-proper and the city of Philadelphia are 10-15% lower than those recorded for the wider metro areas.
Claire Purnell suggested a compelling reason for Pittsburgh’s lower COVID numbers: Steeler country is neither a destination city nor an airline hub. On the challenging side, first, the Tulsa area has seen a sharp increase in cases during the past two weeks as the President prepares to speak to as many as 62,000 people in an indoor rally venue.
Second, the President and Vice President, the head of the coronavirus task force, fail to set an example for the rest of the country by dispensing with social distancing and the wearing of masks in publicly recorded events. CNN reports that the probability of transmission is about one-in-six with social distancing practiced; it falls to roughly one-in-thirty with the addition of a mask. Third, Dr Anthony Fauci states that he has not met with President Trump for at least half a month.
New and news resources. The New York Times has produced a resource for tracking the current two-week trending of the coronavirus contagion. This remarkable tool indicates a decline in the infection rate in at least 80% of the areas under review with a flat-line for most of the balance. The only up-ticks are in suburban Denver, Howard County (Maryland), and an outlying area of Pittsburgh metro. Southwestern Colorado has confirmed no new cases in the past fortnight.
So, while the overall trend in the United States shows a 9% increase in detection rates, the area under review is improving. Some good news this week as, apparently, a steroid may provide critical care relief for patients suffering severely from COVID-19. This new medicine, Dexamethasone, supplement the mitigating medication, Remdesivir, now being manufactured by Gilead Pharmaceutical.
Beating the odds and data update. As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). .
- World: 8,587,298 cases (up 13%); 456,462 deaths (up 8%); 5.3% mortality rate; one case for very 894 people and one death for every 16,834 people
- United States: 2,237,031 cases (up 9%); 119,747 deaths (up 4%); 5.4% mortality rate; one case for every 148 people and one death for every 2,777 Americans
==========
- Baltimore-Annapolis: 21,585 confirmed cases; 4.8% mortality rate; one death for every 2,723 people
- Boston and the Cape: 61,933 confirmed cases; 7.1% mortality; one death for 1,045 people
- Chicago proper: 86,179 confirmed cases; 5.0%; one death per 912 people
- Colorado statewide: 29,901 cases; 5.5%; one death per 3,524
- Detroit metro: 42,076; 11.3%; 1 death per 903
- New York metro*: 447,478; 8.2%; 1 per 619
- New York CITY: 211,260; 10.5%; 1 per 378
- Manhattan Island 26,109; 9.2%; 1 per 680
- Philadelphia metro: 52,304; 7.5%; 1 per 1,559
- Pittsburgh metro: 3,503 cases; 8.7%; 1 per 7,745
==========
Second Wave Anticipation. While a second wave remains likely, the question remains its magnitude. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place?Answer: open question with the ‘in-a-month’ getting old after two or three months
- Will the states, as a group, have re-opened too soon or too laxly?Answer: most states are thus far okay; Florida is a noticeable exception.
- How much will the current protests of George Floyd's murder re-accelerate penetration?Answer: Trump rally may compound the spread in Oklahoma
- Will the virus have a seasonal effect (e.g., not prolific in hot weather)? Answer: NO.
- Will the virus have mutated and, if so, for the worse or better?
- How long will people prove to be immune who have survived the illness already?Answer: only time will tell; some evidence of either re-infection or protracted infection.
- How quickly can a safe and effective vaccine be developped and tested?Answer: progress on mitigating drugs; vaccine targeted for late 2020 or early 2021
- How efficiently can, and comprehensively will, the vaccine be distributed?Answer: not promising with slowness of testing; concerns over pricing
- How deep will the penetration of COVID-19 be in the rural areas?Answer: slow progression continues but apparently not accelerating.
Friday numbers as at 12jun20
NOTE: U.S. and global static pool rates declined slowly in the first half of the week before flattening out at 14.9% and 10.2%, respectively. These static pool rates carry the same differential as before and remain high above the mortality run rates of 5-6%. All this despite a finding that the spread of the
COVID-19 from passive carriers may be slower than expected. Eventually, the mortality static pool and run rates from this
sixth coronavirus will converge.
¿When the end? The virus will migrate through the population, possible creating a 'herd immunity', and will end with the development and dissemination of
a vaccine. A review of the data presented this week indicates that, if t
his first wave is the extent of the COVID-19 epidemic in the United States, one can reasonably expect the convergence of static pool and mortality run rates at some point in the range of 158-192,000 deaths, roughly a quarter above the best case level of 141,994 deaths
identified ten weeks ago (and about half the base case of 335,301).
WEEK-in-SUMMARY. The flattening of static pool rates at the end of the week possibly augured a second wave.
Certain states started recording increases in cases while the through-put from the first wave still cycled through the system. Additionally, epidemiologists voiced concern that
protestors may amplify the coming spike. To date, the data have remained inconclusive; preliminary, largely anecdotal, evidence indicated that many protestors are wearing masks, partly with the
admonishment of local leaders.
Data Problems. There was a problem, again, with inconsistent data between those reported by
Johns Hopkins and those from
Worldometer, the two sources underlying these updates. Most of the differences appeared to be immaterial, explicable by real-time versus periodic recording. One difference remained material, however: that of the number of people deemed as recovered. The Johns Hopkins datum stayed consistently at two-thirds that of Worldometer.
A review of the respective methodologies revealed what appeared to be a more
conservative counting and confirmation method employed by
Johns Hopkins as opposed to
Worldometer. To address these differences, I split the difference between the two measures on U.S. and global data while, for local data, I relied upon the more granular Johns Hopkins data (with one exception for statewide in Colorado). This method employed the
SWAG approach (S.W.A.G. = scientifically wild-assed guess).
Review of Family Clusters. While the politics of the murder of a black man by the police overwhelmed coverage of the pandemic, the coronavirus contagion surfaced another epidemic of public violence: that
suffered by medical personnel. The share of the areas under review relative to national cases and deaths declined by roughly two percentage points each -- to 35.6% of cases and 48.6% -- indicating the up-tick recorded in twelve, largely
rural states. The mortality run rates in the clusters stayed well above national and global rates (i.e., 7.6% versus 5.6%).
New York metro accounted for 60% of the cases but less than a third of the deaths among the eight areas under review, attesting to Governors Cuomo's (D-NY), Lamont's (D-CT), and Murphy's (D-NJ) effective leadership during the crisis. Only
Detroit metro and Maryland showed significant increases in confirmed cases, likely due to increased testing as mortality run rates fell. The growth of cases worldwide still increased by 13% (versus 8% for the U.S. and 3% for the family clusters) led again by India, Brazil, and, perhaps, Russia.
Second Wave Anticipation. The timely topic for discussion remains that of a second wave. There will be one, almost certainly, but the question remains its magnitude. No one can say what that wave will be like. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place?
Answer: perhaps in the next month for testing.
- Will the states, as a group, have re-opened too soon or too laxly? Answer: indications of spikes in Florida and Arizona; but no spike yet in Georgia.
- How much will the current protests of George Floyd's murder re-accelerate penetration? Answer: too soon to tell; wait a fortnight.
- Will the virus have a seasonal effect (e.g., not prolific in hot weather)? Answer: unlikely to be a seasonal pattern due to heat as evidenced by current spikes in India and Brazil.
- Will the virus have mutated and, if so, for the worse or better? Answer: wait and see.
- How long will people prove to be immune who have survived the illness already? Answer: only time will tell; some evidence of either re-infection or protracted infection.
- How quickly can a safe and effective vaccine be developped and tested? Answer: three vaccines are under phase-3 (advanced) F.D.A. testing; possible vaccine in 2020, more likely early 2021.
- How efficiently can, and comprehensively will, the vaccine be distributed? Answer: undetermined, but the the dissemination of now available tests remains slow; concerns energing over the pricing of such a future vaccine.
- How deep will the penetration of COVID-19 be in the rural areas? Answer: some evidence of penetration but extent and pace remain unknown.
- How will rural areas manage with fewer available facilties, medical first responders, and Medicaid extensions? Answer: that is the concern; mobile hospital capacity may help.
Beating the Odds and Data Update. As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). .
- World: 7,599,437 cases; 423,748 deaths; 5.6% mortality rate (improved from 5.9%); one case for very 1,011 people and one death for every 18,134 people
- United States: 2,060,221 cases; 115,011 deaths; 5.6% mortality rate (improved from 5.7%); one case for every 161 people and one death for every 2,891 Americans
==========
- Baltimore-Annapolis: 20,295 confirmed cases; 4.8% mortality rate; one death for every 2,892 people
- Boston and the Cape: 60,969 confirmed cases; 7.0% mortality; one death for 1,079 people
- Chicago proper: 83,978 confirmed cases; 4.9%; one death per 962 people
- Colorado statewide: 28,647 cases; 5.5%; one death per 3,647
- Detroit metro: 41,487; 11.6%; 1 death per 912
- New York metro*: 442,696; 8.2%; 1 per 626
- New York CITY: 208,517; 10.6%; 1 per 381
- Manhattan Island 25,725; 9.2%; 1 per 688
- Philadelphia metro: 50,969; 7.4%; 1 per 1,618
- Pittsburgh metro*: 3,394 cases; 8.7%; 1 per 7,981
* Pittsburgh metro numbers appear to be unrealistically optimistic
Friday numbers as at 05jun20
NOTE: U.S. static pool rates dropped sharply until a slight up-tick for today at 15.9%, reflecting a
gradual trend back up since Decoration Day. Global static pool rates trended down more slowly to 11.4%, roughly 30% below the U.S. rate; slowing the decline are the current challenges facing the
U.K. (14.2% mortality run rate) and
Brazil.
The concern over U.S. static rates relates to an expected second wave. Compounding the risk of re-opening too soon is the effect of widespread protests across the country following the police murder of George Floyd. This new risk factor has two dimensions: the
break-down of the discipline exercised for the previous two months by many Americans and the
effects of tear gas.
Between Memorial Day celebrations and protests, social distancing has declined, especially in urban areas with fewer people wearing masks.
Masks keep the virus in by containing droplets of spittle; it does not keep the virus out. That is to say: people who do not wear masks can still spread the virus to those who do. These hazards of the protests will not create, but aggravate, the second wave.
Global infection levels increased by 13% with increased detection in India, the Middle East and South America. Meanwhile global static pool rates declined, indicating higher testing levels as proven by mortality run rates declining modestly from 6.1% to 5.9%. U.S. confirmed cases grew 6% with a similar improvement in the mortality run rate of two-tenths of a per cent to 5.7%.
Growth rates for four of the clusters straddled the 6% national rate, with Baltimore-Annapolis (+14%) and Colorado (+9%) being the outliers. New York and Detroit recorded the slowest growth rates of 2-3%, again reflecting disciplined mitigation. Detroit's tragically high mortality run rate of 13% reflects the age and minority demographics of its metropolitan population.
Despite slightly declining shares of the confirmed cases and deaths, the areas studied still endure mortality run rates that are a third above the national rate (i.e., 7.6% versus 5.7%). A quarter of the way into the year time-horizon of this statistical (
¿sadistical?) tracking, it might be helpful to see how the current numbers across the U.S. compare with those
forecast two months ago.
- Actual Results after three months: 1,904,678 cases and 109,403 deaths
- Best Case for one year: @3,500,000 guesstimated cases (actual to scenario cases of 55% or 55% of the way there) and 141,994 deaths (actual to forecast deaths of 77% or three-quarters of the way there)
- Base Case for twelve months: 9,313,895 cases (actual to projected of 21%) and 335,301 of deaths (actual to anticipated of 32%)
- Worst Case through 28feb21: @33,263,911 cases (6% of the way there) and 1,197,501 (9% of the way there)
- Stress case for the 1918 Flu (i.e., its three years compressed into one): 95,000,000 cases (2%) and 2,166,706 deaths (5%).
These numbers indicate that disciplinary mitigants are working thus far, before a second wave. While the number of deaths roughly tracks those of the base case, it is too soon to be confident with these data. The Spanish Flu had an ultimate mortality run rate of 2.3%, while the projections for this pandemic are higher at roughly 3.6%. In the end, the level of penetration is the key driver.
The 2.2 million death rate of the Stress Case datum is the source of
President Trump's misleading statement that he has prevented "millions of deaths" from the "Wuhan Plague". While the computation is correct, the final funeral toll for the coronavirus contagion will not be known for a year and a half, likely more.
The timely topic for discussion remains that of a second wave. There will be one, almost certainly, but the question remains its magnitude. No one can say what that wave will be like. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place?
- Will the states, as a group, have re-opened too soon or too laxly?
- How much will the current protests of George Floyd's murder re-accelerate penetration?
- Will the virus have a seasonal effect (e.g., not prolific in hot weather)?
- Will the virus have mutated and, if so, for the worse or better?
- How long will people prove to be immune who have survived the illness already?
- How quickly can a safe and effective vaccine be developped and tested?
- How efficiently can, and comprehensively will, the vaccine be distributed?
- How deep will the penetration of COVID-19 be in the rural areas?
- How will rural areas manage with fewer available facilties, medical first responders, and Medicaid extensions?
As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). .
- World: 6,715,334 cases; 393,342 deaths; 5.9% mortality rate (improved from 6.1%); one case for very 1,144 people and one death for every 19,535 people
- United States: 1,904,678 cases; 109,403 deaths; 5.9% mortality rate (unchanged); one case for every 174 people and one death for every 3,040 Americans
==========
- Baltimore-Annapolis: 18,252 confirmed cases; 4.7% mortality rate; one death for every 3,131 people
- Boston and the Cape: 59,680 confirmed cases; 7.0% mortality; one death for 1,113 people
- Chicago proper: 80,713 confirmed cases; 4.8%; one death per 1,028 people
- Colorado statewide: 27,360 cases; 5.5%; one death per 3,818
- Detroit metro: 37,165; 12.9%; 1 death per 969
- New York metro*: 436,261; 8.2%; 1 per 635
- New York CITY: 205,406; 10.6%; 1 per 386
- Manhattan Island 25,317; 9.2%; 1 per 703
- Philadelphia metro: 49,040; 7.3%; 1 per 1,710
- Pittsburgh metro: 3,259 cases; 8.9%; 1 per 8,146
* New York metro mis-stated last week at 437,456 rather than 428,456
Friday numbers as at 29may20
NOTE: U.S. static pool rates trended down modestly for the first half of the week under review before leveling off and hovering at the 19% mark. While this rate remains roughly 50% above the global static pool rate. also trending down with a slack momentum, it is not necessarily bad news. Remember how U.S. health officials sought to flatten the curve?
Our favourite docs have largely succeeded, and this is what a flattened curve looks like as the U.S. infection and mortality rates mature and slowly taper off during this first and, hopefully, only wave of the pandemic. One warning from these data -- both domestic and global -- is that some places are enduring up-ticks in illness and death as others slow down.
Growth rates in confirmed cases slowed again for the eight areas under study, with the exception of Baltimore-Annapolis. The areas under review are facing steeper challenges than the rest of the Union at this point. Specifically, they comprise four every ten cases and a little over half of the deaths nationwide, but represent only 16% of the population.
Together, the 'family compounds' endure mortality run rates a third above the national rate (i.e., 7.8% versus 5.9%). There are three reasons for our 'skewed up' family.
- We live primarily in urban areas where higher population density and an older demographic.
- We live in areas that tend to have advanced medical facilities to enable more testing.
- We tend to live East of the Mississppi, showing the less contained transmission from Europe than from Asia.
The timely topic for discussion remains that of a second wave. There will be one, almost certainly, but the question remains its magnitude. No one can say what that wave will be like. Answers to the following questions will go a long way in determining the magnitude of that wave.
- Will there be adequate testing and tracing in place?
- Will the states, as a group, have re-opened too soon or too laxly?
- Will the virus have a seasonal effect (e.g., not prolific in hot weather)?
- Will the virus have mutated and, if so, for the worse or better?
- How long will people prove to be immune who have survived the illness already?
- How quickly can a vaccine be developped and tested?
- By truncating the usual testing guidelines, how safe and effective will that vaccine be?
- How efficiently can, and comprehensively will, the vaccine be distributed?
- How deep will the penetration of COVID-19 be in the rural areas?
- How will rural areas manage with fewer available facilties, medical first responders, and Medicaid extensions?
The projections of the consequences of the coronavirus contagion that I put together almost two months ago still stand. That
projection only covers the first year of the virus (i.e., the best case timeline of vaccine development and roll-out; through 28feb21). That timeline allows for two waves. The results correspond to potential wave magnitudes:
- 2nd wave as weaker than first wave (i.e., best case; ebbing tide) of 141,994 deaths;
- 2nd wave as larger than the first wave (i.e., base case; rising tide) of 335,301 deaths;
- 2nd wave as much larger than the first wave (i.e., worst case; high and stormy tide) of 1,197,501 deaths; as well as,
- 2nd wave as a tsunami (stress case; replication of mortality levels relative to the total U.S. population of 1918 Flu) of 2,166,706 deaths.
The final 2.2 million datum is the source or President Trump's misleading statement that he has prevented the epidemic from being 20-25x worse. While the computation is correct, the final funeral toll for the coronavirus contagion will not be known for at least two years. Globally confirmed cases and deaths rose 14% last week while the number of deaths grew at half that rate.
Improvements are likely coming from earlier testing, better equipment, and a slower pace of infection in particularly afflicted areas. The U.S. cases climbed by 10%, significantly slower than global infection rates, but parallelled the worldwide increase in deaths at 7%. These domestic data probably reflect increased testing at an earlier stage in the American pandemic curve.
As one reviews these data, (s)he ought to keep in mind the likelihood of a death, expressed as one death for every X people (i.e., the odds). Pittsburgh and Colorado are substantially more safe than the average mortality of the U.S. population. PGH numbers are suspiciously low, given the older demographic and the 2.4 million population. Colorado's numbers may be understated as the state withheld date for today (29may20). Baltimore-Annapolis remains a little safer than average.
- World: 5,934,521 cases; 363,751 deaths; 6.1% mortality rate (improved from 6.9%); one case for very 1,295 people and one death for every 22,125 people
- United States: 1,761,163 cases; 103,230 deaths; 5.9% mortality rate (unchanged); one case for every 188 people and one death for every 3,253 Americans
==========
- Baltimore-Annapolis: 16,576 confirmed cases; 4.9% mortality rate; one death for every 3,464 people
- Boston and the Cape: 55,532 confirmed cases; 7.0% mortality; one death for 1,196 people
- Chicago proper: 75,306 confirmed cases; 4.8%; one death per 1099* people
- Colorado statewide: 25,121 cases; 5.7%; one death per 4,063
- Detroit metro: 36,239; 11.8%; 1 death per 1,005
- New York metro: 428,456*; 8.3%; 1 per 641
- New York CITY: 201,051; 10.7%; 1 per 391
- Manhattan Island 24,619; 9.1%; 1 per 722
- Philadelphia metro: 46,697; 7.2%; 1 per 1,823
- Pittsburgh metro: 3,123 cases; 9.1%; 1 per 8,289
* Chicago mortality odds adjusted to reflect Cook County; previous odds recalculated** New York metro mis-stated last week at 437,456 rather than 428,456
Friday numbers as at 22may20
NOTE: U.S. static pool rates trended down at a slowing velocity to 21.8% (i.e., only two percentage points lower than 15may20) and still 50% than the global static rate of 14.5%. This continuing 50% gap primarily reflects the maturity of the U.S. epidemic (30% of the global coronavirus contagion) trailing that of the European pandemic. This assessment assumes that differences among countries like demographics and health-care quality and availability tend to cancel each other out.
This week saw a much wider re-opening of state, primarily rural, economies. The concern commanding media attention is the Depression-level unemployment of forty million jobs sliced across the United States in two months and the proposed beneficiaries of already unaffordable Federal aid. Nevertheless, the national epidemic remains uncertain as some reports indicate cases accelerating in l
ess densely populated areas of the country. Overall U.S case confirmation and death rates grew by 10-11% during the week.
This trend of the COVID-19 away from the larger cities specifically affected case confirmation and mortality rates in northern Maryland (+20% & +18%), Eastern Pennsylvania (+10% & +12%), and Colorado (+11% & +20%). Among urban centres, only Chicago showed a high growth in case confirmation (+11%) and mortality (+16%) as the windy city appears not to have peaked. Otherwise, New York and Detroit showed much slower rates of growth (3-4% & 3-8%).
Americans are showing
mixed feelings about, and trust-levels toward, a vaccine; much of this may be a consequence of the political division renting the social fabric. Gone are the days of universal welcoming of, and trust toward, the Salk vaccine. Amid this division, the up-tick in cases in the rural and 'red' states becomes important due to the lack of hospitals after many closures; fewer and fewer qualified medical first responders; as well as, the absence of Medicaid extension.
The countries that the American government should study for lessons learned in the event of a second wave of the COVID-19 pandemic or a new virus are Germany, Canada, Japan, Australia, and South Korea. South Korea (51.2 million), Japan (125.5 million) and Germany (80.2 million) for larger populations and higher population densities. Australia (25.5 million) and Canada (37.7 million) share large land masses.
Globally confirmed cases and deaths rose 16% last week, indicating more testing and a higher level of data integrity on attributing cause of death. Please be advised that the scaling factor is important here since mortality run-rates and growth rates may appear to be high but the overall penetration of a certain cluster's area remains low. The 'odds' of dying in various places calculate the number of COVID-19 deaths of a given cluster relative to its population. This calculation renders the data from the various clusters comparable in assessing their relative gravity.
- World: 5,179,515 cases; 344,537 deaths*; 6.7% mortality rate (unchanged); one case for very 1,483 people and one death for every 22,303 people
- United States: 1,600,048 cases; 95,557 deaths; 6.0% mortality rate (unchanged); one case for every 208 people and one death for every 3,481 people
=====
- Baltimore-Annapolis: 14,555 confirmed cases; 4.9% mortality rate; one death for every 3,942 people
- Boston and the Cape: 53,317 confirmed cases; 6.9% mortality; one death for 1,272 people
- Chicago proper: 67,551 confirmed cases; 4.6%; one death per 1,270 people
- Colorado statewide: 23,191 cases; 5.7%; one death per
- Detroit metro: 35,348; 11.7%; 1 death per 1,040
- New York metro: 419,439; 8.1%; 1 per 664
- New York CITY**: 190,357; 10.7%; 1 per 399
- Manhattan Island 23,943; 9.2%; 1 per 736
- Philadelphia metro: 43,813; 7.1%; 1 per 1,986
- Pittsburgh metro: 2,934 cases; 9.4%; 1 per 8,591
* Yours truly mis-calculated last week's death toll for the U.S.; that number was approximately 300,000
* New York City numbers misstated at 17,000; correct number 190,357
Friday numbers as at 15may20
NOTE: U.S. static pool rates trended down the first half of the last week, but levelled out at 23.8%, eight percentage points above the global static pool rate. Again, this steady 50% margin of the American over global rates likely reflects the trailing maturation of the U.S. epidemic vis à vis the global pandemic.
The news is positive for now as U.S. mortality run-rates fell slightly, with improvements in New York and a slower trend in Detroit; only Pennsylvania showed significantly more than a 5% growth in cases. Nationally, cases increased 15% with deaths up 14%. The slight relative improvement is due more likely to increased testing. Please note a constraint in the static pool calculations, explained in the comment section below.
The criticism of President Trump's handling of the coronavirus contagion has been intense and, at least from the view of the lateness to respond, largely justified. Nevertheless, the numbers of deaths per million in the United States compares favourably with most other developped countries. One large constraint facing the U.S. is the scale of territory and population.
The countries that the American government should study for lessons learned in the event of a second wave of the COVID-19 pandemic or a new virus are Germany, Canada, Japan, Australia, and South Korea. South Korea (51.2 million), Japan (125.5 million) and Germany (80.2 million) for larger populations and higher population densities. Australia (25.5 million) and Canada (37.7 million) share large land masses.
In fairness to the Administration,
certain success stories are emerging and should be acknowledged. Among the areas studied inside the United States, Pittsburgh may merit further examination due to the low number of cases. As always, one must be sceptical with data that appear to be outliers. China provides a an
excellent example of questionable data at their face.
Recording very few cases over the last two months implies a successful Chinese lock-down of the pandemic's epicentre of Wuhan and the host-province of Hubei. Nevertheless, Hubei comprises 4% of China's population but accounts for 81% of the recorded cases and 97% of the deaths. When remote places like the Faroe Islands record higher incidence rates than China, wariness is the order of the day. One should praise China's efforts
but not accept her data without reservation.
The calculations for the 'odds' of dying places the number of COVID-19 deaths of a given cluster relative to its population. This calculation renders the data from the various clusters comparable in their relative gravity.
- World: 4,452,425 cases; 297,595 deaths; 6.7% mortality rate; one case for very 1,725 people and one death for every 25,821 people
- United States: 1,448,012 cases; 86,945 deaths; 6.0% mortality rate; one case for every 229 people and one death for every 3,825 people
=====
- Baltimore-Annapolis: 12,070 confirmed cases; 5.0% mortality rate; one death for every 4,655 people
- Boston and the Cape: 45,272 confirmed cases; 6.7% mortality; one death for 1,402 people
- Chicago proper: 58,457 confirmed cases; 4.7%; one death per 1,439 people
- Colorado statewide: 20,838 cases; 5.2%; one death per 5,278
- Detroit metro: 34,185; 11.4%; 1 death per 1,104
- New York metro: 405,215; 8.2%; 1 per 691
- New York CITY: 190,357; 10.9%; 1 per 410
- Manhattan Island 23,056; 8.9%; 1 per 795
- Philadelphia metro: 39,696; 6.9%; 1 per 2,218
- Pittsburgh metro: 2,723 cases; 9.6%; 1 per 9,016
NOTE: New York Metro's 'odds' were erroneously calculated at one death for every 427 the previous week; the recalculation for that week is 732.NEW York City's odds were misstated in the previous week; that number should be 427
Friday numbers as at 08may20
NOTE: Happy 75th
V.E. Day. U.S. static pool rates trended down the first half of the last week, but up-ticked to 27.2% on Thursday and Friday. The slight increase does not lend itself to causation, particularly the inference that several states have
re-opened pre-maturely. While that possibility remains likely, one can not yet prove it.
Eventually static pool rates will decline to a level close to the mortality run-rate. The determinants of the pandemic's severity rests on the long-term penetration rate among Americans and the long-term steady-state mortality run-rate. As a reference, the penetration rate, across the United States, of the
1918 Spanish Flu levelled out at roughly 28%, with a long-term mortality run-rate of 2.3%.
For those skeptical of the recent anti-social distancing policies, were those Spanish Flu rates repeated today with current U.S. population in excess of 3x that of a century ago, the number of confirmed cases would approach 94 million, with more than two million compatriots succumbing to the disease. People need to guard against the temptation to celebrate as final the modest improvement in recent figures for two reasons:
- the highly transmissible nature of the virus itself; as well as,
- static-pool mortality rates still being 6.5x the first year forecasted run-rate of 3.6% and a current global static pool rate well below that of the United States (i.e., 27% versus 16%).
Such an increase from a second wave is likely in the first year of the coronavirus contagion, especially with widespread testing
turning up cases without symptoms. Nevertheless, other factors may accelerate or decelerate penetration and mortality (e.g., the benefit of
allaying drugs like remdesevir, seasonality, effective
anti-bodies, etc.).
This week's information adds one datum for each geographic segment: the odds of dying from the coronavirus. One calculates this ratio by dividing the area population by the number of deaths recorded in that area. This statistic will give one a sense of scale. For example, assume that one looks at Chicago and Pittsburgh mortality rates only,
That person would initially conclude that Chicago is doing a superb job as indicated by her 4.4% mortality run rate versus the far poorer 9.2% rate recorded for Pittsburgh. Except that Pittsburgh has a much lower population penetration rate. Consequently, Pittsburghers currently have a one in 10,000+ chance of dying from COVID-19.
Yet Chicagoans are eight times more likely to die with odds of one in every 1,300 people. The difference between the global mortality odds of one in 28,000+ versus one in 4,000+ in the United States may indicate the infancy of the global pandemic that has yet to diffuse itself completely around the world, while the coronavirus contagion rapidly penetrates urbanised populations of wealthier, more urbanised, countries.
Using the American odds of one death among every four thousand people as a median and benchmark, one can infer that Baltimore, Colorado, and Pittsburgh are doing well at this stage
- World: 3,911,087 cases; 271,039 deaths; 6.9% mortality rate; one death for every 28,351 people
- United States: 1,259,083 cases; 76,420 deaths; 6.1% mortality rate; one death for every 4,353 people
=====
- Baltimore-Annapolis: 10,132 confirmed cases; 4.7% mortality rate; one death for every 5,913 people
- Boston and the Cape: 45,272 confirmed cases; 6.2% mortality; one death for 1,655 people
- Chicago proper: 48,341 confirmed cases; 4.4%; one death per 1,859 people
- Colorado statewide: 18,371 cases; 5.1%; one death per 6,100
- Detroit metro: 32,327; 11.0%; 1 death per 1,206
- New York metro: 386,248; 8.0%; 1 per 732
- New York CITY: 180,216; 10.9%; 1 per 427
- Manhattan Island 21,662; 8.7%; 1 per 869
- Philadelphia metro: 34,551; 6.4%; 1 per 2,757
- Pittsburgh metro: 2,512 cases; 9.2%; 1 per 10,272
Friday numbers as at 01may20
NOTE: Happy International Labour Day. U.S. static pool rates trended down consistently during the week by one-fifth to the current level of 29% versus a slightly improved global rate of 19%. While this is good news, the U.S. static pool rates remain 50% above the global rates and 8x above the projected eventual mortality rate of 3.6%.
The measures taken across most states are slowing infection rates, perhaps suggesting a peak. Such a peak could mean that, if the curve / parabola were symmetric -- i.e., what goes up comes down in an identical manner -- the United States would be about half way through the coronavirus contagion. This conclusion, however, is tenuous for the following reasons:
As it is, the U.S. comprises roughly a third of the confirmed cases world-wide. A lot of the current discussion in the press, the medical fraternity, and the government alike centres
on a second wave. If like the Spanish Flu of a century ago, this second wave could be worse. In most cases, with other flues as a fuzzy parallel, it should not be. The hunt for a vaccine continues with a
hopeful roll-out in early 2021.
Much of the related publicity has become
political and economic; tensions boil over in states with stricter controls due to economic stress and a general climate of anger. Among the family clusters, New York and Chicago showed the most encouraging results while Boston, Detroit and Pittsburgh endured significantly higher death rates during the last week
- World: 3,283,435 cases; 233,781 deaths; 7.1% mortality rate
- United States: 1,082,665 cases; 63,445 deaths; 5.9% mortality rate
=====
- Baltimore-Annapolis: 7,491 confirmed cases; 4.6% mortality rate
- Boston and the Cape: 38,965 confirmed cases; 5.6% mortality
- Chicago proper: 36,515 confirmed cases; 4.4%
- Colorado statewide: 15,284 cases; 5.1%
- Detroit metro: 30,584; 10.3%
- New York metro: 358,203; 7.7%
- New York CITY: 167,478; 10.8%
- Manhattan Island 19,837; 8.1%
- Philadelphia metro: 29,060; 5.1%
- Pittsburgh metro: 2,263 cases; 8.4%
Friday numbers as at 24apr20
NOTE: U.S. static pool rates remained erratic over the past week. Though thee range was lower than last week, between 35.3% and 37.1%, the latter percentage represented the calculation of Friday 24th April as U.S. static pool rates started back up. The global static pool rate remained basically unchanged at 20.2%, still significantly below U.S. levels.
What may portend a downward change in static pool rates for the U.S. versus the rest of the world is that 1.9% of U.S. active cases are in critical care versus 3.1% of global cases;
I would advise against relying too heavily on these findings since figures are distorted by incomplete or inaccurate reporting and under-testing in other parts of the world. Since U.S. cases represent close to a third of global cases, the high U.S. static pool rates may be shrouding signs of maturing infection rates elsewhere.
Though New York Metro represents more than a third of U.S. cases, its trends are slowing, not yet declining. Bloomberg Philanthropy, Johns Hopkins (Mayor Mike's alma mater) and New York State are now taking aggressive measures to help the CITY out by implementing a
contact-tracing programme. The politics is getting testy and down-right strange; if interested, please consult the many rants careening across social media.
- World: 2,779,078 cases; 194,333 deaths; 7.0% mortality rate
- United States: 891,657 cases; 50,533 deaths; 5.7% mortality rate
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- Baltimore-Annapolis: 5,977 confirmed cases; 3.7% mortality rate
- Boston and the Cape: 29,241 confirmed cases; 4.0% mortality
- Chicago proper: 25,811 confirmed cases; 4.4%
- Colorado statewide: 11,262 cases; 4.9%
- Detroit metro: 27,450; 9.1%
- New York metro: 319,966; 7.7%
- New York CITY: 150,473; 10.9%
- Manhattan Island 17,803; 7.6%
- Philadelphia metro*: 22,810; 4.4%
- Pittsburgh metro: 1,999 cases; 7.4%
* Number of deaths incorrectly stated last week for Philadelphia as 115,924; correct datum of 15,924 deaths
Friday numbers as at 17apr20:
NOTE: U.S. static pool rates (i.e., deaths / [deaths+recoveries] are trending down slightly from 40% to 38% over the last week, implying that the U.S. may be peaking now but the data are not yet actionable as the rate is high. These arresting rates, in the face of lower global static pool rates (21%) may be attributable to people dying after ten days to weeks after extraordinary measures creating a lag-time or over-hang of mortality.
These data bear out Governor Cuomo's contention that the longer one is on a ventillator, the more certain (s)he will face the ultimately adverse outcome. Now remember: complaisance can kill, but only one out of every ten thousand Americans have died thus far. There is no reason to panic; mortality rates will also come down as the United States ramps up her testing, now at 3.4 million.
Medical student, Lucas Kogut, who is entering residency, sheds some light on
how the coronavirus works and why Dr Bill Bauer's concern over complaisance applies; reading this, one can only pray for medical first responders. Perhaps the grimmest part of this experience, thus far not as lethal as expected, is the
toll it is taking on the nation's Blacks and other peoples of colour.
- World: 2,211,877 cases; 150,673 deaths; 6.8% mortality rate
- United States: 685,003 cases; 35,062 deaths; 5.1% mortality rate
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- Baltimore-Annapolis: 4,023 confirmed cases; 2.5% mortality rate
- Boston and the Cape: 20,404 confirmed cases; 3.5% mortality
- Chicago proper: 18,087 confirmed cases; 4.0%
- Colorado statewide: 8,675 cases; 4.3%
- Detroit metro: 23,298; 7.6%
- New York metro: 258,007; 6.5%
- New York CITY*: 123,146; 9.3%
- Philadelphia metro: 15,924; 3.5%
- Pittsburgh metro**: 1,487 cases; 5.0%
* Johns Hopkins now breaks out N.Y.C. boroughs Manhattan: 15,539 cases; 6.0% mortality rate
** Pittsburgh now includes Butler.
PGH without Butler: 1,333 cases; 4.9% mortality rate
Friday numbers as at 10apr20:
NOTE: U.S. static pool rates (i.e., deaths / [deaths+recoveries] are still rising from 37% at 41% over the last week, implying that the U.S. either is peaking now or has not peaked yet. These rates will fall as more people recover. These arresting rates may also be attributable to a lag in testing across the country.
- World: 1,639,473 cases; 99,331 deaths; 6.1% mortality rate
- United States: 475,601 cases; 17,878 deaths; 3.75% mortality
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- Baltimore-Annapolis: 2,634 confirmed cases; 2.2% mortality rate
- Boston and the Cape: 12,044 confirmed cases; 1.8% mortality
- Chicago proper: 11,415 confirmed cases; 3.1%
- Colorado statewide: 6,202 cases; 3.6%
- Detroit metro: 17,760; 5.2%
- New York metro: 187,033; 4.3%
- New York CITY: 87,028; 6.1%
- Philadelphia metro: 11,280; 2.0%
- Pittsburgh metro: 1,078 cases; 2.3%
Friday numbers as at 03apr20:
One explkanatory factor here for the difference between the rates of say Philly, Boston, and Pittsburgh may be the presence of ample medical facilities and teaching hospitals.
- World: 1,062,051 cases; 56,255 deaths; 5.3% mortality rate
- United States: 258,762 cases; 6,596 deaths; 2.5% mortality
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- Baltimore-Annapolis: 1,155 confirmed cases; 1.1% mortality rate
- Boston and the Cape: 5,620 confirmed cases; 1.3% mortality
- Chicago proper: 5,575 confirmed cases; 1.9%
- Colorado statewide: 3,728 cases; 2.6%
- Detroit metro: 9,022; 4.2%
- New York metro: 109,447; 2.0%
- New York CITY: 57,159; 2.7%
- Philadelphia metro: 2,100; 0.6%
- Pittsburgh metro: 558 cases; 0.7%